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折扣/货期| 货号：SIH-386-1MG | 规格：1 mg | 目录价：￥2448 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Sphingosine-1-phosphate, D-erythro
别名:
[(E,2S,3R)-2-Amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
产品描述:
Signaling molecule
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
379.5
产品形式:
White solid
产地:
加拿大
功能与背景:
D-erythro-Sphingosine-1-phosphate (S1P) is a polar sphingolipid metabolite which regulates diverse cellular responses including cell growth, survival and migration. S1P was reported to stimulate DNA synthesis and cell division in quiescent cultures of Swiss 3T3 fibroblasts and to trigger the dual signal transduction pathways of calcium mobilization and PC-PLD (phospholipase D) activation. S1P serves as a second messenger for intracellular calcium mobilization in U-937 cells (sc-2239) and decreases cellular cAMP. Recent studies show that S1P is a G-protein-coupled receptor (GPCR) ligand for the EDG-1 family, including EDG-1, -3, -5, -6 and -8. This bioactive lipid mediator has been shown to stimulate the ERK pathway and to also counteract the ceramide-induced activation of stress-activated protein kinase (SAPK/JNK). Researchers have also found that S1P is a strong inhibitor of cell motility and phagokinesis in B16 melanoma cells. Additionally, it induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells. S1P has also been known as a tumor-promoting lipid. Suggested to be an activator of GPR3, GPR6, and GPR12. D-erythro-Sphingosine-1-phosphate is an activator of EDG-1, EDG-3, EDG-2, EDG-4 and EDG-5.¬
纯度:
>98%
来源:
Synthetic
CAS号:
26993-30-6
分子式:
C18H38NO5P
溶解度:
Sparingly soluble in 1:1 ethanol:water. Addition of small amounts of acetic acid may help dissolve this product. Soluble in warm methanol.
PubChem CID:
5283560
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