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折扣/货期| 货号：CDX-S0330-G001 | 规格：1 g | 目录价：￥3682 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Sunitinib malate
别名:
Sunitinib L-malate; SU112248; N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt
产品描述:
Sunitinib malate is a potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR, PDGFR-beta and c-Kit (Ki = 2-17nM). It inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Sunitinib malate inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib malate exhibits potent antiangiogenic and antitumor activity in multiple xenograft models. It decreases VEGF- and FGF-induced proliferation of human umbilical vein endothelial cells (HUVECs) and reduces tumor growth in a variety of mouse xenograft models when administered at doses ranging from 20 to 80 mg/kg per day.
宿主来源:
Synthetic
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
532.56
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
341031-54-7
分子式:
C22H27FN4O2 . C4H6O5
促销活动
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