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折扣/货期| 货号：AG-CN2-0544-M001 | 规格：1 mg | 目录价：￥1080 |
| 货号：AG-CN2-0544-M005 | 规格：5 mg | 目录价：￥4320 |
| 货号：AG-CN2-0544-M010 | 规格：10 mg | 目录价：￥7080 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Taspine
别名:
Thaspine; NSC 76022; NSC 618155; NSC 688259
产品描述:
Taspine is an alkaloid with multifunctional pharmacological properties, including apoptosis-inducing, anti-angiogenic, anticancer, cytotoxic, anti-inflammatory and wound-healing activities, thereby modulating multiple targets. Taspine is a potent acetylcholinesterase (AChE) inhibitor and wound healing promoter (cicatrizant), by regulating the expression of keratinocyte growth factor (KGF; FGF-7) in early phases. Taspine has anticancer properties targeting DNA topoisomerase IB and was shown to be a dual topoisomerase inhibitor. Taspine is an apoptosis-inducing compound. It induces conformational activation of the pro-apoptotic proteins Bak and Bax, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. It induced tumor apoptosis in vitro and in vivo. Taspine can inhibit tumor angiogenesis acting as a multi-target VEGFR-2 inhibitor. Taspine was shown to downregulate VEGF expression and inhibit the proliferation of vascular endothelial cells through PI3 kinase and MAPK signaling pathways. The anti-angiogenic activity of taspine may depend on its EGF secretion properties and therefore the modulation of the EGFR signaling pathways, mediating MAPK (Erk1/2) but Akt signals. Taspine is a human P2X4 receptor inhibitor, mediating its effect through PI3-kinase inhibition. Activation of P2X4 is associated with inflammation involving peripheral and central inflammatory cell types. It also has been shown to act as a potent TLR2 antagonist, contributing to its anti-inflammatory properties.
宿主来源:
Isolated from Croton lechleri.
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
369.4
产品形式:
solid
产地:
瑞士
纯度:
>98% (1H-NMR)
CAS号:
602-07-3
分子式:
C20H19NO6
促销活动
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