TNFSF11 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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TNFSF11 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-959

规格：0.05 mg

目录价：￥10126

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TNFSF11 Recombinant Protein

别名:

RANKL,CD254,TRANCE,OPGL,ODF

实验应用:

ELISA,WB

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

PBS, pH7.4

产地:

美国

生产商:

Prosci

功能与背景:

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.

纯度:

>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized Human TNFRSF11A at 5 ug/mL (100 uL/well) can bind Human TNFSF11, His Tag with a linear range of 0.2-6 ng/mL.

Accession #:

AAC51762.1

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