UCH-L3 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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UCH-L3 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-960

规格：0.1 mg

目录价：￥8687

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

UCH-L3 Recombinant Protein

别名:

UCHL3,Ubiquitin thioesterase L3

实验应用:

表达系统:

E. coli

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

50 mM Tris, 150 mM NaCl, pH7.5

产地:

美国

生产商:

Prosci

功能与背景:

Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3), a member of peptidase C12 family, is also known as ubiquitin thioesterase L3. Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. UCH-L3 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCH-L3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is also required for stress-response retinal, skeletal muscle and germ cell maintenance. Furthermore, UCH-L3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

纯度:

>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.

Accession #:

AAH18125

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