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折扣/货期| 货号：CDX-X0005-M025 | 规格：25 mg | 目录价：￥3920 |
| 货号：CDX-X0005-M050 | 规格：50 mg | 目录价：￥6202 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Xanthohumol
别名:
2',4,4'-Trihydroxy-6'-methoxy-3'-prenylchalcone
产品描述:
Xanthohumol is a cell-permeable natural prenylated chalcone isolated from the hop plant, H. lupulus. Xanthohumol and its metabolites induce protective detoxification enzymes, at least in part via the nuclear factor erythroid-2-related factor 2 pathway. Xanthohumol can have anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic and osteogenic effects. Xanthohumol binds to the N-terminal domain of p97 ATPase (VCP; valosin-containing protein), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of p97 ATPase thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Xanthohumol inhibits diacylglycerol acetyltransferase (DGAT) and human P450 enzymes. It also inhibits the expression of HIF-1alpha and VEGF under hypoxic conditions.
宿主来源:
Plant
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
354.4
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>98% (NMR)
CAS号:
6754-58-1
分子式:
C21H22O5
溶解度:
Soluble in DMSO (10mg/ml) or ethanol (10mg/ml).
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