官网链接
折扣/货期| 货号：CDX-G0208-M250 | 规格：250 mg | 目录价：￥644 |
| 货号：CDX-G0208-G001 | 规格：1 g | 目录价：￥2030 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Glimepiride
别名:
trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide; Amaryl; HOE 490
产品描述:
Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic beta-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-beta (Abeta) in neurons in a PPARgamma-dependent manner.
宿主来源:
Synthetic.
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
490.62
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
93479-97-1
分子式:
C24H34N4O5S
促销活动
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